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Author: Admin | 2025-04-28
Capability of swallowing tablets. Prednisolone may be preferred in patients with hepatic dysfunction due to the potential risk of variability in concentrations that may occur in prednisone due to the extensive liver metabolism of prednisone into its active form. Based on dosage forms, the oral solution of prednisolone has a higher concentration available for a more cost-effective option compared to the prednisone solution. With a higher concentration of prednisolone solution available, a higher dose can be achieved with less solution. Medications can be hard to administer in children and the least amount of solution they need to try and swallow, especially if they do not like the potentially unfavorable taste, the better. In addition to smaller quantities being administered, prednisolone tends to have a better taste than many other liquid corticosteroids. This is why you may frequently see prednisolone liquid used over prednisone in pediatric patients. Note that dexamethasone may have the largest amount of evidence supporting its use for an indication like croup. To summarize, liver function, disease state, dose needed, swallowing ability, age, taste, insurance, and product availability/cost in the United States may be a deciding factor in choosing prednisone versus prednisolone.This article was written by Leah Lowenberg, PharmD Candidate in collaboration with Eric Christianson, PharmD, BCPS, BCGPFor more on corticosteroids and prednisolone specifically, check out this podcast episode. Did you enjoy this blog post? Subscribers are emailed new blog posts TWICE per week! In addition, you’ll get access to the free giveaways below. Over 6,000 healthcare professionals have subscribed for our FREE Giveaways. Why haven’t you?!30 medication mistakes PDF18+ Page Drug Interaction PDF10 Commandments of Polypharmacy Webinar based on my experiences in clinical practiceCitations: Prednisolone. IBM Micromedex Solutions. Truven Health Analytics, Inc. Ann Arbor, MI. Accessed January 22, 2024. http://www.micromedexsolutions.comPrednisone. IBM Micromedex Solutions. Truven Health Analytics, Inc.
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