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Author: Admin | 2025-04-28
Inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit. The injection should be discarded if the solution is discolored or contains a precipitate.DosageDosages of promethazine hydrochloride by the various routes of administration are identical.Because of the risk of potentially fatal respiratory depression, promethazine hydrochloride should not be used in children younger than 2 years of age. The drug should be used cautiously and at the lowest effective dosage in older children (See Cautions: Pediatric Precautions.)Allergic ConditionsAs an antihistamine, promethazine hydrochloride usually is given at bedtime because of its pronounced sedative effects. The usual adult oral dose of promethazine hydrochloride is 25 mg before retiring; if necessary, however, 12.5 mg may be administered before meals and on retiring. Children 2 years of age and older may receive a single bedtime dose of up to 25 mg or up to 12.5 mg 3 times daily depending on the age and weight of the child. Alternatively, children 2 years of age and older may be given 0.5 mg/kg at bedtime or 0.125 mg/kg as needed. Dosage should be adjusted to the smallest amount adequate to relieve symptoms.When the oral route is not feasible, 25 mg of promethazine hydrochloride may be given rectally or IM; if required, the drug may be administered by IV injection (see Dosage and Administration: Administration and see Cautions: Precautions and Contraindications). This dose may be repeated within 2 hours if necessary, but oral therapy should be instituted as soon as possible if further medication is necessary.To prevent or control minor allergic transfusion reactions in adults, 25 mg of promethazine hydrochloride may be administered prior to or during a blood transfusion.Motion SicknessFor the management of motion sickness, adults may be given 25 mg of promethazine hydrochloride and children may receive 12.5–25 mg or 0.5 mg/kg. The first dose should be given at least 30–60 minutes prior to departure. A second dose may be given 8–12 hours later if necessary. Additional doses may be given on arising in the morning and before the evening meal for the duration of the journey.Common ColdFor the temporary relief
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