Comment
Author: Admin | 2025-04-28
CRD summaryThis review assessed the efficacy and safety of trazodone for the treatment of erectile dysfunction. The authors' tentatively concluded that trazodone may be a helpful treatment for erectile dysfunction, particularly at higher doses and in men with psychogenic erectile dysfunction. The authors discussed some of the limitations of the review and rightly advised caution when interpreting the findings.Authors' objectivesTo determine the efficacy and safety of trazodone for the treatment of erectile dysfunction (ED).SearchingMEDLINE was searched from 1966 to the end of May 2002; the search terms were listed. The reference lists in identified reports and reviews were checked and abstracts from national AUA meetings were handsearched (January 1995 to May 2002). In addition, the Cochrane Library and the specialised register of the Cochrane Prostatic Diseases and Urological Cancers Group were screened for further studies. Studies in any language were eligible.Study selectionStudy designs of evaluations included in the reviewRandomised controlled trials (RCTs) that lasted at least 7 days were eligible for inclusion. Both parallel-group and crossover RCTs were included.Specific interventions included in the reviewStudies that compared trazodone with placebo or an active control treatment were eligible for inclusion. The included studies compared trazodone (50 to 200 mg, most commonly 150 mg) with either placebo, hypnotic suggestion, ketanserin or mianserin. Trazodone was administered as monotherapy in all studies but one, where it was used in combination with yohimbine. The duration of treatment in the included studies ranged from 4 to 13 weeks.Participants included in the reviewStudies that included men with ED were eligible for inclusion. The mean age of the participants in the included studies ranged from 38 to 65 years (mean 48 years). The cause of ED was definite or probable psychogenic ED in about 80% of men, vascular in about 9%, diabetes-related in 5%, and of mixed or unknown
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