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Author: Admin | 2025-04-28
Generic name: codeine / guaifenesinMedically reviewed by Drugs.com. Last updated on Feb 27, 2024.Note: This document provides detailed information about Virtussin A/C Side Effects associated with codeine / guaifenesin. Some dosage forms listed on this page may not apply specifically to the brand name Virtussin A/C.Applies to codeine / guaifenesin: oral liquid, oral syrup. Codeine can slow or stop your breathing, and may be habit-forming. MISUSE OF THIS MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription.Do not give this medicine to anyone under 18. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.Like other narcotic medications, codeine can slow your breathing. Death may occur if breathing becomes too weak.A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.Stop using this medicine and call your doctor at once if you have:noisy breathing, sighing, shallow breathing;a slow heart rate or weak pulse;severe dizziness or drowsiness;confusion, hallucinations, unusual thoughts or behavior;little or no urinating;severe constipation; orslow heart rate, weak or shallow breathing.Serious side effects may be more likely in older adults and those who are overweight, malnourished, or debilitated.Common side effects may include:constipation; ormild drowsiness.This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. For healthcare professionalsApplies to codeine/guaifenesin: oral capsule, oral liquid, oral syrup, oral tablet.General adverse eventsThe more commonly reported adverse effects of codeine include nausea, vomiting, and diarrhea. Guaifenesin is generally well tolerated.Nervous systemFrequency not reported: CNS depression, lightheadedness, dizziness, sedation, headache, convulsions, weakness[Ref]Codeine CardiovascularFrequency not reported: Tachycardia, bradycardia, palpitation, faintness, syncope, orthostatic hypotension, circulatory depressionCodeine GastrointestinalFrequency not reported: Nausea, vomiting, constipation, biliary tract spasm, increased colonic motility, toxic dilationGuaifenesin: Frequency not reported: Abdominal pain (upper), diarrhea, nausea, vomiting[Ref]Codeine GenitourinaryFrequency not reported: Oliguria, urinary retention, antidiuretic effect[Ref]Codeine DermatologicCodeine: Frequency not reported: RashGuaifenesin: Frequency not reported: Rash[Ref]Codeine-induced rash may be related to direct stimulation of histamine release.[Ref]HypersensitivityFrequency not reported: Pruritus, giant urticaria, angioneurotic edema, laryngeal edemaGuaifenesin: Frequency not reported: Hypersensitivity reactions (pruritus, urticaria)Codeine OcularFrequency not reported: Visual disturbancesCodeine PsychiatricFrequency not reported: Euphoria, dysphoria, transient hallucination, disorientationCodeine RespiratoryCodeine: Frequency not reported: Respiratory depression[Ref]Respiratory depression and death have occurred in children who received codeine in the postoperative period following tonsillectomy and/or adenoidectomy. Further investigation has shown these patients to be ultra-rapid metabolizers of codeine. Children with obstructive sleep apnea who are treated with codeine appear to be particularly sensitive to the respiratory depressant effects of codeine.[Ref]References1. de Groot AC, Conemans J (1986) "Allergic urticarial rash from
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