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Author: Admin | 2025-04-28
Tablets)NO TABLET IN THE EVENINGDrug Interaction ProfileModerate CYP3A inhibitors including1: fluconazole, erythromycinDosing ConsiderationsALTERNATE TABLETS EVERY MORNINGDAY 1: elexacaftor 50 mg/tezacaftor 25 mg/ivacaftor 37.5 mg(2 orange tablets)DAY 2d: ivacaftor 75 mg(1 light blue tablet)NO TABLET IN THE EVENING What to do if a dose is missed1 MISSED MORNING DOSE If ≤6 hours have passed, take as soon as possible and take evening dose as scheduledIf >6 hours have passed, take the missed dose as soon as possible but do not take evening dose and continue as scheduled the following day MISSED EVENING DOSE If ≤6 hours have passed, take as soon as possible and take next morning dose as scheduledIf >6 hours have passed, do not take missed dose and take next morning dose as scheduled the following day If ≤6 hours have passed, take as soon as possible and take evening dose as scheduledIf >6 hours have passed, take the missed dose as soon as possible but do not take evening dose and continue as scheduled the following day If ≤6 hours have passed, take as soon as possible and take next morning dose as scheduledIf >6 hours have passed, do not take missed dose and take next morning dose as scheduled the following day Morning and evening doses should not be taken at the same time eGFR, estimated glomerular filtration rate; lb, pounds.cContinue dosing with 2 elexacaftor/tezacaftor/ivacaftor tablets twice a week, approximately 3 to 4 days apart.1dContinue dosing with 2 elexacaftor/tezacaftor/ivacaftor tablets and 1 ivacaftor tablet on alternate days.1 IMPORTANT SAFETY INFORMATIONWARNING: DRUG-INDUCED LIVER INJURY AND LIVER FAILURETRIKAFTA can cause serious and potentially fatal drug-induced liver injury. Cases of liver failure leading to transplantation and death have been reported in patients with and without a history of liver disease taking TRIKAFTA, in both clinical trials and the postmarketing setting.
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