Comment
Author: Admin | 2025-04-28
Expected to start workingIn a majority of users, Lexapro won’t facilitate noticeable therapeutic effects until it has been used for 4 to 8 weeks. Persons who respond to Lexapro in 4 to 8 weeks could be considered “normal” responders (due to the fact that this is when it’s most common to notice the medication working). That said, a small percentage of individuals may need even longer than 8 weeks for the medication to start working or reach peak therapeutic effect – these individuals could be considered “late” or “delayed” responders.Listed below are some reasons as to why Lexapro may take longer than you expect to start working or “kick in.” Possible reasons as to why Lexapro can take 4 to 8+ weeks to manage your symptoms include: neurophysiologic adaptations that occur over weeks (such as 5-HT1A receptors and hippocampal neurogenesis) and/or adjustments in dosing (such as titrating the Lexapro dosage upwards from a subtherapeutic quantity). Realize that there might be additional explanations (other than those provided) as to why Lexapro may require a reasonable amount of time to start working.Lexapro gradually downregulates 5-HT1A receptorsIn certain Lexapro users, it is likely that 5-HT1A receptors need to decrease (i.e. downregulate) before a therapeutic effect occurs. Until 5-HT1A receptor downregulation occurs, a subset of users may not notice Lexapro working. Despite the fact that Lexapro increases extracellular serotonin signaling on the first day of administration, substantial 5-HT1A downregulation usually doesn’t occur until the medication has been used for several weeks.The chief reason 5-HT1A
Add Comment