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Author: Admin | 2025-04-28
The pills, he or she opens the packets, releasing the antagonists, which prevent the opioid from working. The packets are supposed to stay sealed if taken by mouth, however, so that the pills continue to work for legitimate patients.Some companies are working on molecules that require something in the digestive system, such as an enzyme, to activate the opioid. It’s as if both the painkiller and the euphoric effect of the medicine are locked up and there’s no way to unlock them without first putting them through your entire GI tract.* * *When Purdue first came out with the reformulated OxyContin, it wasn’t allowed to say the new pill was abuse-deterrent because there wasn’t yet evidence it made a difference to abusers. It sounded like it should work, but who’s to say? “Drug users can be very inventive and so your best efforts may not work very well in practice,” says Wilson Compton, director of epidemiology, services and prevention research at the U.S.’ National Institute on Drug Abuse.Now, just enough time has passed for researchers to check the effects of having the new OxyContin on the market for a few years. This past April, the U.S. Food and Drug Administration approved an abuse deterrent claim on OxyContin’s label based on newly published scientific studies.Nearly all of the studies were funded by Purdue. That doesn’t necessarily mean they’re biased. It’s common practice for drug companies to bankroll the surveillance of their own products, and of course Purdue would like to know if Intac actually works. It helps that there have been several studies that ask slightly different questions about Intac’s effect on abuse and together, they point toward Intac working, Compton says.“The effect is significant and appears to be clinically meaningful,” he says.Studies based on the industry-funded Researched Abuse, Diversion and Addiction-Related Surveillance system found that since the introduction of Intac-enabled OxyContin, the amount of the drug diverted for abuse fell by up to 60 percent. The number of poison control calls about overdosing on OxyContin fell by 42 percent. The median street value of a new OxyContin pill is 63
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