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Author: Admin | 2025-04-28
2014; Levy 2009; Ornoy 2006; Sokal 2019; Stathopoulos 2011).Bisphosphonates are incorporated into the bone matrix and gradually released over time. The amount available in the systemic circulation varies by drug, dose, and duration of therapy. Theoretically, there may be a risk of fetal harm when pregnancy follows the completion of therapy (hypocalcemia, low birth weight, and decreased gestation have been observed in some case reports); however, available data have not shown that exposure to bisphosphonates during pregnancy significantly increases the risk of adverse fetal events (Djokanovic 2008; Green 2014; Levy 2009; Sokal 2019; Stathopoulos 2011). Exposed infants should be monitored for hypocalcemia after birth (Djokanovic 2008; Stathopoulos 2011).Until additional data are available, most sources recommend discontinuing bisphosphonate therapy in females of reproductive potential as early as possible prior to a planned pregnancy. Use in premenopausal females should be reserved for special circumstances when rapid bone loss is occurring; a bisphosphonate with the shortest half-life should then be used (Bhalla 2010; Pereira 2012; Stathopoulos 2011).Oral bisphosphonates can be considered for the prevention of glucocorticoid-induced osteoporosis in premenopausal females with moderate to high risk of fracture who do not plan to become pregnant during the treatment period and who are using effective birth control (or are not sexually active); intravenous therapy should be reserved for high risk patients only (Buckley [ACR 2017]). Patient EducationWhat is this drug used for?It is used to prevent or treat soft, brittle bones (osteoporosis). It is used to treat Pagets disease. It may be given to you for other reasons. Talk with the doctor.Frequently reported side effects of this drugHeadache Nausea Vomiting Abdominal pain Constipation DiarrheaOther side effects of this drug: Talk with your doctor right away if you have any of these signs of:Low calcium like muscle cramps or spasms, numbness and tingling, or seizures Black,
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