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Author: Admin | 2025-04-28
Of azithromycin, plasma concentrations decrease in a polyphasic manner, leading to an average terminal half-life of about 68 hours.[37] The long half-life and extensive tissue and intracellular distribution permit once-daily dosing and a shorter course of treatment than other antimicrobials. For example, a chlamydia infection may be treated with a single 1 g dose of azithromycin versus 100 mg of doxycycline twice daily for 7 days.Elimination: Biliary excretion is the primary route for eliminating unchanged medication following oral administration.[38] Administration Available Dosage Forms and StrengthsOral formulations include tablets (250 mg, 500 mg), packets (1 gram dissolved in ¼ cup or 60 mL of water), and suspension for reconstitution (100 mg/5 mL, 200 mg/5 mL). These formulations can be administered with or without food.Intravenous (IV) azithromycin is available in a 500 mg preservative-free solution for reconstitution. IV azithromycin should be infused over at least 60 minutes. Azithromycin should not be administered via intramuscular injection or IV bolus.Ophthalmic azithromycin solution (1%) for bacterial conjunctivitis is available in a 2.5 mL bottle.The extended-release formulation of azithromycin has been discontinued.Adult DosageThe standard dose is 250 or 500 mg, once daily, for 3 to 5 days. Higher doses are typically reserved for severe infections. A single 1 g dose may be given for adults with chlamydia. Acute otitis media: For patients 6 months and older, azithromycin may be given in a single 30 mg/kg dose, or 10 mg/kg once daily for 3 days, or 10 mg/kg on Day 1, followed by 5 mg/kg/d for the next 4 days.Community-acquired pneumonia: For patients 6 months and older with an infection due to C pneumoniae, H influenzae, M pneumoniae, or S pneumoniae, the recommended dosage is 10 mg/kg orally as a single dose on Day 1, followed by 5 mg/kg/d orally for the next 4 days. Azithromycin is usually combined with third-generation cephalosporins, such as ceftriaxone.[39]Acute bacterial sinusitis: The azithromycin dosage is 10 mg/kg orally once daily for 3 days. Pharyngitis/tonsillitis: For patients 2 years and older with pharyngitis or tonsillitis caused by S pyogenes, azithromycin is given at 12 mg/kg orally once daily for 5 days, with
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